About us

Centre for Human Drug Research

CHDR is a full service contract research organisation (CRO) located in Leiden, The Netherlands. We provide a full spectrum of high quality clinical pharmacology services to the (bio-) pharmaceutical industry.

 We are collaborative partners, offering sophisticated advice to our clients on all aspects of the process of drug development. We have long-standing relationships with many of our clients, enabling us to anticipate their service needs. Thus, we speed up the process and make it more efficient. We also offer added value because of our own research programs; we develop new biomarkers, optimise our clinical research methods and add new knowledge and expertise to our consultancy. This synergy of services results in a unique CRO that operates on a high scientific level but remains focused on our clients’ objectives.

Clinical studies

CHDR specialises in data-intensive, early phase, clinical studies where pharmacokinetic and pharmacodynamic parameters are obtained. Studies First-in-humans PK/PD modelling Proof-of-concept. Our fields of expertise:

• Central Nervous System
• Cardiovascular system
• Metabolism
• Pulmonary diseases
• Allergy
• Immunology
• Pediatrics

 We have a team of volunteer recruiters, statisticians, data management developers, pharmacists and quality assurance managers who work in a fully integrated manner to support our state-of-the-art studies. Combining this team with an innovative technologically supported workflow, we deliver accurate and high quality data which meet current GCP and GMP standards.

Biomarker Development

CHDR has a wide-ranging self-funded research program where biomarkers are explored for pharmacological responses or other indicators related to a therapeutic intervention. Technologies are developed and validated primarily to obtain detailed mechanistic information for use at the earliest clinical stage. Hence, we are able to establish decision points earlier, and thereby improve drug development timelines.

Technologies:

• Various challenge models: CNS, Inflammation, Allergen
• CNS test battery
• Various imaging techniques: PET, MRI, fMRI, phMRI, RS-MRI
• Non-invasive airway inflammometry: eg exhaled and nasal NO, EBC, sputum
• Stable isotope administration
• Genomics and metabolomics
• Circadian Rhythm
• etcetera

Consultancy services

Another added value is that CHDR employs medical experts who leverage their pharmacological know-how to efficiently guide the drug development process. Their input guarantees the success of every project throughout all stages

• Draw up plans to address all regulatory, safety and efficacy issues relating to the drug candidate.
• Evaluate the available and appropriate technologies
• Write medical documentation.

In close collaboration with academic hospitals and universities, CHDR has developed experience in virtually all therapeutic areas.