Centre for Human Drug Research

Clinical trials

Theses

CHDR has published  a large number of PhD-Theses:

10-09-2009 Diderik Boot
Non-invasive sampling methods of inflammatory biomarkers in asthma and allergic rhinitis (3MB)

30-11-2008 Sanne de Haas
Pharmacological differences of GABAergic compounds: a pharmacodynamic characterization (3MB)

04-06-2008 Kari Franson
Provision and assessment of pharmacology and pharmacotherapy education across an integrated medical school curriculum (8MB)

28-05-2008 Lineke Zuurman
Clinical pharmacology of cannabinoids in early phase drug development (3MB)

24-05-2007 Martijn van Doorn
Evaluation of molecular profiling platforms in clinical pharmacology (3MB)

26-09-2006 Jeroen van der Post
Biomarkers in early phase development of central nervous system drugs: a conceptual framework

01-10-2003 Madelon Buijs
Metabolic implications of reduced growth hormone availability in abdominal obesity

10-09-2003 Saco de Visser:
A question based approach to drug development

10-09-2003 Ingrid Kamerling:
Clinical target validation for a non-peptide motilin receptor antagonist

22-05-2003 Michiel Kemme:
Endothelial function determined from systemic plasma concentrations -release of tissue factor pathway inhibitor and binding of tissue plasminogen activator

24-10-2002 Harm Gijsman:
Pharmacological aspects of challenge tests of the serotonergic system of the brain

02-10-2002 Richard Faaij:
The clinical pharmacology of antithrombotic compounds

12-09-2002 Olga Weijtens:
Dexamethasone in ophthalmology -pharmacokinetics after various routes of administration

04-03-1999 Rik Schoemaker:
Modelling repeated measurements in clinical pharmacology; from individual to population and back

17-12-1998 Cees Kroon:
Variability in subcutaneous absorption and clearance of anticoagulant drugs

26-03-1998 Koos Burggraaf:
Liver blood flow in clinical pharmacology assessment with echo-Doppler

22-09-1993 Fred van Steveninck:
Methods of assessment of central nervous system effects of drugs in man

The following CHDR PhD thesis is available on request:

Jean van Griensven: Causes of variability in the pharmacokinetics of thrombolytic drugs

 


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