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A crossover study evaluating the sex-dependent and sensitizing effects of sleep deprivation using a nociceptive test battery in healthy subjects.

23 August 2022. doid: 10.1111/bcp.15505

Hijma H, Koopmans I, Klaassen E, Doll RJ, Zuiker R, Groeneveld GJ

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We assessed whether total sleep deprivation (TSD) in combination with pain tests yields a reliable method to assess altered pain thresholds, which subsequently may be used to investigate (novel) analgesics in healthy subjects.

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