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Key publication
61
Pain
Methods & challenges

Key publication

Effects of Selective Sphingosine-1-Phosphate Receptor 1 Agonist, TRV045, on Evoked Pain Tests: An Exploratory, Four-Way Cross-Over Study in Healthy Volunteers

Key publication

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

Key publication

Respiratory and Antinociceptive Effects of Nociceptin Receptor-µ-Opioid Receptor Agonist Cebranopadol versus Full Opioid Receptor Agonist Oxycodone: A Comparison in Healthy Volunteers.

Key publication

Esketamine effect on remifentanil-induced depression of the acute hypoxic ventilatory response: a volunteer study

Key publication

Intranasal naloxone reversal of opioid-induced respiratory depression in opioid-naïve individuals and self-reported daily opioid users.

Key publication

Low-dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug-drug interaction study

Key publication

Fentanyl-induced Ventilatory Depression: Population Pharmacokinetic-Pharmacodynamic Framework for Evaluation of Opioid-induced Ventilatory Depression.

Key publication

Tolerant to Tolerance.

Key publication

Cannabidiol Increases Psychotropic Effects and Plasma Concentrations of Δ-Tetrahydrocannabinol Without Improving Its Analgesic Properties.